Blood Components

Separating Components from Whole Blood Fibrinogen Fibrinogen is a high molecular weight protein occurring in the plasma in quantities of 100 to 700 mg/dl.  In the presence of calcium ions it becomes the precursor for fibrin threads the foundation of the blood clot.  In terms of replacement therapy, a target value of 150 mg/dl may […]

Coagulopathies & Treatment

Coagulopathies & Treatment The most common cause of intraoperative coagulopathy is thrombocytopenia (decrease in platelet count) secondary to hemodilution.  Blood loss that is replaced by crystalloid volume will progressively dilute platelet numbers as well as platelet entrapment on the surfaces of the extracorporeal circuit.  Associated with bypass is platelet migration to the spleen and reticuloendothelial […]